Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Aug 15;29(16):1677–1682. doi: 10.1101/gad.261677.115

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 Chen et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

Figure 2. — Neurofibromin regulation of NSC multilineage differentiation is MEK-dependent. (A) The astrocyte, oligodendrocyte, and neuronal differentiation defects observed in Nf1^−/− TVZ NSCs were restored to wild-type (WT) levels following PD901, but not MK2206, treatment. (B) PD901-treated Nf1^BLBP conditional knockout mice exhibited reduced astrocyte numbers compared with vehicle-treated controls. n = 4 per group. No change in astrocyte numbers were observed following BKM120 treatment. n = 4 per group. (C) Densitometric analyses of pERK^T202/Y204, pAKT^S473, and pAKT^T308 immunoblots relative to total ERK and AKT levels. n = 4 per group. Error bars denote the mean ± SD. (veh) Vehicle. Bar, 100 μm. (*) P < 0.05; (**) P < 0.01.