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. 2015 Aug 15;29(16):1677–1682. doi: 10.1101/gad.261677.115

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© 2015 Chen et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — Neurofibromin loss in NSCs results in MEK-dependent Jagged1/Notch activation. Neurofibromin loss resulted in increased Jagged1 and cleaved Notch1 (NICD) expression in vitro (A) and in vivo (B) relative to controls. While MK2206 treatment did not reduce Jagged1 and NICD expression (C), PD901 treatment reduced Nf1-deficient NSC Jagged1 and NICD expression to wild-type (WT) levels (D). (E) Increased Jagged1 and NICD expression was observed in the TVZ of Nf1^BLBP conditional knockout (CKO) mice, which was ameliorated by PD901, but not BKM120, treatment. n = 4 per group. (veh) Vehicle.