Table 2.
Meta-analysis on the effect of the CTLA-4 SNP rs231775 for AAD
| Study name | A AAD | G AAD | A Ctrls | G Ctrls | Odds ratio for G (95% CI) | Z-value | P-v alue | Relative weight | |
|---|---|---|---|---|---|---|---|---|---|
| UK Euradrenal |
AAD N=309; Ctrls N=335 |
361 | 257 | 400 | 260 | 1.10 (0.88–1.37) | −0.80 | 0.425025 | 28.13 |
| Norway Euradrenal |
AAD, N=382; Ctrls, N=380 |
382 | 370 | 437 | 313 | 1.35 (1.10–1.66) | −2.90 | 0.003688 | 33.87 |
| Brozzetti et al.3 |
AAD, N=180; Ctrls, N=394 |
214 | 146 | 578 | 210 | 1.88 (1.44–2.44) | −4.69 | 0.000003 | 20.31 |
| Donner et al.21 |
AAD, N=76 Ctrls; N=394 |
85 | 67 | 581 | 358 | 1.28 (0.91–1.81) | −1.39 | 0.163298 | 11.73 |
| Perez de Nanclares et al.22 |
AAD, N=57; Ctrls, N=111 |
75 | 39 | 160 | 62 | 1.34 (0.83-2.18) | −1.19 | 0.235072 | 5.96 |
| TOTAL random modela |
AAD, N=1002; Ctrls, N=1614 |
1121 | 885 | 2136 | 1186 | 1.37 (1.13–1.66) | −3.15 | 0.002 |
Meta-analysis was performed using the program ‘Comprehensive meta-analysis version 2.0’ (www.meta-analysis.com), random effects model. Significant associations are marked with bold text in the P-value column.
aBeslow-Day test of heterogeneity: P=0.05; Hedges’s g test of heterogeneity: P=0.05.