Summary of findings 5. Summary of findings table 5.
| Insecticide treated uniforms versus no intervention for preventing leishmaniasis | |||||
|
Patient or population: People at risk of CL or VL Settings: CL or VL endemic areas Intervention: Insecticide treated uniforms Comparison: No intervention | |||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (trials) | Quality of the evidence (GRADE) | |
| Assumed risk | Corresponding risk | ||||
| No intervention | Insecticide treated uniforms | ||||
| Vector density | ‐ | ‐ | ‐ | (0 trials) | ‐ |
|
CL cases > 12 months follow‐up |
52 per 1000 |
21 per 1000 (7 to 62) |
RR 0.40 (0.13 to 1.20) |
558 (2 trials) |
⊕⊕⊝⊝ low1,2,3,4,5 |
|
VL cases > 2 years follow‐up |
‐ | ‐ | (0 trials) | ‐ | |
| *The basis for the assumed risk is provided in footnotes. The corresponding risk (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; RR: risk ratio; CL: cutaneous leishmaniasis; VL: visceral leishmaniasis. | |||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | |||||
1The risk of CL in the control groups was 7% in Iran (Asilian 2003a IRN) and 13% in Colombia (Soto 1995 COL). To be consistent with the other 'Summary of findings' tables, we presented an assumed risk of 5.2%. 2Downgraded by 1 for serious risk of bias: Trials are at high or unclear risk of selection bias and reporting bias. 3No serious inconsistency: Although, one trial reported a statistically significant difference and one does not, this is likely related to the low CL incidence in the trial finding no difference. 4No serious indirectness: In both Iran and Colombia, soldiers were randomized to wear permethrin treated uniforms (concentration of 850 mg/m²) or standard uniforms. 5Downgraded by 1 for serious imprecision: The 95% CI of the overall effect is wide and includes clinically important effects and no difference.