Summary of findings 6. Summary of findings table 6.
| Multifaceted intervention versus no intervention for preventing leishmaniasis | |||||
|
Patient or population: People at risk of CL or VL Settings: CL or VL endemic areas Intervention: Multifaceted intervention Comparison: No intervention | |||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (trials) | Quality of the evidence (GRADE) | |
| Assumed risk | Corresponding risk | ||||
| No intervention | Multifaceted intervention | ||||
| Vector density | ‐ | ‐ | ‐ | 0 trials | ‐ |
|
CL cases 12 months follow‐up |
13 per 1000 | 6 per 1000 |
RR 0.42 (0.13 to 1.41) |
3631 (1 trial) |
⊕⊝⊝⊝ very low1,2,3 |
|
VL cases > 2 years follow‐up |
‐ | ‐ | ‐ | 0 | ‐ |
| *The basis for the assumed risk (for example, the median control group risk across trials) is provided in footnotes. The corresponding risk (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: risk ratio; CL: cutaneous leishmaniasis; VL: visceral leishmaniasis; ITNs: insecticide treated bednets. | |||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | |||||
1Downgraded by 1 for serious indirectness: This trial was conducted in urban areas of Colombia using a multifaceted intervention with ITNs, bars of insect repellent and permethrin painted trunks. Further studies with other combination of interventions and different settings would increase confidence in this result. 2Downgraded by 1 for serious risk of bias: the trial is at high or unclear risk of selection bias and reporting bias. 3Downgraded by 1 for serious imprecision: The 95% CI of the overall effect is wide and includes clinically important effects and no difference.