Table 1:
Body of Evidence Examined According to Study Design
| Study Design | Number of Eligible Studies |
|---|---|
| RCTs | |
| Systematic review of RCTs | 5 |
| Large RCT | 6 |
| Small RCT | |
| Observational Studies | |
| Systematic review of non-RCTs with contemporaneous controls | |
| Non-RCT with non-contemporaneous controls | |
| Systematic review of non-RCTs with historical controls | |
| Non-RCT with historical controls | |
| Database, registry, or cross-sectional study | |
| Case series | |
| Retrospective review, modelling | |
| Studies presented at an international conference | |
| Expert opinion | |
| Total | 11 |
Abbreviations: RCT, randomized controlled trial.