Effects of guanfacine treatment on paired-pulse ratio. (A and
B), individual paired-pulse ratios calculated in neurons recorded in PFC
slices from PBS-treated male and female mice. (C), mean values of
paired-pulse ratio in neurons recorded in PFC slices from PBS-treated male and female
mice. (D and E), individual paired-pulse ratios calculated
following chronic guanfacine (14 days, 0.15 mg/kg) administration in neurons recorded in
PFC slices from male and female mice. (F), mean values of paired-pulse ratio
in neurons recorded in PFC slices from PBS-treated male and female mice. (G
and H), individual AMPA/NMDA ratios calculated in neurons recorded in PFC
slices from PBS-treated male and female mice. (I), mean values of AMPA/NMDA ratio in
neurons recorded in PFC slices from PBS-treated male and female mice. (J and
K), individual AMPA/NMDA ratios calculated in neurons recorded in PFC
slices from guanfacine-treated male and female mice. (L), mean values of
AMPA/NMDA ratio in neurons recorded in PFC slices from guanfacine-treated male and female
mice.