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| Experiment | Treatment | Dose(s) of guanfacine | Regimen | Assay performed | Other assays |
|---|---|---|---|---|---|
| 1 | Guanfacine | 0 to 0.3 mg/kg | Acute (30 min before test) | Forced swim | Body temperature |
| 2 | Guanfacine | 0 to 0.3 mg/kg | Chronic (once daily, 15 days) | Forced swim | Locomotion |
| 3 | Guanfacine + Physostigmine | 0.15 mg/kg | Acute, separate injections | Light/Dark, Forced swim | c-fos immunoreactivity |
| 4 | Guanfacine | 0.15 mg/kg | Chronic (once daily, 15 days) | Electrophysiological recording of PFC neurons |
