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. Author manuscript; available in PMC: 2015 Sep 7.
Published in final edited form as: Nutr Res. 2015 Jun 30;35(9):834–843. doi: 10.1016/j.nutres.2015.06.007

Table 1.

Information on C elegans strains

Strains Gene deficient Human homologs Functions References
Wild type (N2) – – – [7,59]
daf-16(mgDf50)I daf-16 Forkhead box protein O (FOXO) Caenorhabditis elegans daf-16 has a central role in mediating the downstream insulin signaling pathways and is the major target of the daf-2 pathway. [8]
daf-16(mgDf50)I; daf-2(m65)III daf-16 and daf-2 FOXO and insulin/IGF-1 receptor The C elegans daf-2 gene encodes the homolog of the mammalian insulin receptor, which has preserved ligand-binding and tyrosine kinase domains [8]
sir-2.1(ok434)IV sir-2.1 NAD-dependent protein deacetylase sirtuin-1 The sir-2.1 transgene functions upstream of daf-16 in the insulin-like signaling pathway; regulates lifespan independently. [42]