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. Author manuscript; available in PMC: 2015 Sep 7.
Published in final edited form as: Nat Neurosci. 2015 Mar;18(3):351–359. doi: 10.1038/nn.3950

Figure 3. Feed-back inhibition in cortical and thalamic microcircuits.

Figure 3

(a) In the cortex, inhibitory SOM interneurons provide a feed-back inhibition to pyramidal neurons that excite them. Loss of this inhibition (eraser*) has been implicated in temporal lobe epilepsy (TLE)37. (b) In the somatosensory thalamus, inhibitory interneurons provide a robust feed-back inhibition to TC neurons that excite them. Increasing this feed-back inhibition (dumbbell weight *) by Zolpidem, or by clonazepam in α3H126R mice (not shown69), which specifically affects RT-TC but not RT-RT connections, enhances epileptiform oscillations. Pyr, pyramidal; SOM, somatostatin-positive; RT, reticular thalamic neuron; TC, thalamocortical neuron.