Changes in skin sympathetic nerve activity (SSNA) during physical stress involving 2 min of 30% maximal isometric handgrip (A) and mental stress involving 2 min of mental arithmetic (B) for rosacea and age/sex-matched controls. Values are means ± SE. In A, significant differences occur between group (rosacea vs. control, P < 0.01), across time (P = 0.03), and in the interactive term (P = 0.03). In B, significant differences occur between group (rosacea vs. control, P = 0.04), but there is no significant difference across time (P = 0.37) or in the interactive term (P = 0.35).