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. 2015 Jul 7;4(7):e246. doi: 10.1038/mtna.2015.18

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Copyright © 2015 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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8-mer LNAs inhibit the growth of a miR-372-positive human gastric tumor. (a) TL372+373 (TL) dose-dependent effects on tumor growth: the horizontal bars inside the boxes indicate the median and the capped bars the minimal and the maximal data values (n = 5) of the relative tumor size increase during the 14 days following the first day of injection. (b) Representative images of LATS2 immunostaining in GC10 xenografts treated with either TLCo or an equimolar TL372+TL373 mix at 5 nanomoles/mouse. Scale bars, 25 μm.