Fig. 4.

Smooth estimates of the average mean diffusivity (MD) of all controls (blue) and patients (red) are plotted versus position from tract origin (cerebral motor cortex (0%) − cerebellar peduncles (100%)), faceted by tract name (corticospinal (CST), somatosensory (Somato), cortico-ponto-cerebellar (CPC), cerebellar-thalamo-cortical (CTC)) and hemisphere (left (L) and right (R) ± pointwise 99% confidence range (light gray shading)). Tract position at 0–5% represents precentral and postcentral gyrus layers, at 47–58% represents thalamic layers in all tracts and at 95–100% represents the spinal cord in CST and somatosensory tracts, and position of the medial cerebellar and superior cerebellar peduncles connecting the brainstem and cerebellum for the CPC and CTC tracts respectively. ‘N’ denotes tract locations with non-significant values.