Inactivation of RV strain Wa in oyster tissues by HPP. RV strain Wa (106 PFU) was added to the feed water during oyster growth. At day 3 postinoculation, oysters were harvested and treated with HPP at 200, 300, 400, and 500 MPa at 4°C for 2 min. After treatment, five oysters in each treatment were homogenized, and the surviving RV was quantified by plaque assay. Data are the means of three replicates. Error bars represent standard deviations.