TABLE 5.
Examples of α-linolenic acid–derived oxylipin functions1
| α-Linolenic acid–derived oxylipin functions | |
| COX oxylipins | |
| 9-HOTrE | Associated with glomerular hypertrophy in obese rats (55) |
| 9,16-diHOTrE | Inhibits PG synthesis from COX1 and collagen-induced human platelet aggregation (80) |
| 13-HOTrE | Suppresses IL-1β–induced expression of matrix metalloproteinases in human chondrocytes in vitro (273) |
| Associated with glomerular hypertrophy in obese rats (55) | |
| 13-HpOTrE | Causes moderate and reversible depression in action potential markers in rat cardiomyocytes (274) |
| 13-oxo-OTrE | Induces glucose uptake and promotes adipocyte differentiation in murine model (275) |
| CYP oxylipins | |
| 9,10-DiHODE | Lower in blood of hyperlipidemic vs. normolipidemic persons (54) |
| 12,13-DiHODE | Lower in blood of hyperlipidemic vs. normolipidemic persons (54) |
1
COX, cyclooxygenase; CYP, cytochrome P450; diHODE, dihydroxy-octadecadienoic acid; diHOTrE, dihydroxy-octadecatrienoic acid; HOTrE, hydroxy-octadecatrienoic acid; HpOTrE, hydroperoxy-octadecatrienoic acid; oxo-OTrE, oxo-octadecatrienoic acid.