Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Vitamin B-12 in 1-carbon metabolism. Vitamin B-12 deficiency prevents remethylation of homocysteine to methionine; results in an accumulation of 5-methyl-THF, or “folate trap,” decreasing the THF pool for synthesis of 10-formyl-THF; and impairs subsequent purine and thymidylate synthesis. MTHFD1, methylenetetrahydrofolate dehydrogenase 1; MTHFR, methylenetetrahydrofolate reductase; MTR, methionine synthase; tHcy, total homocysteine; THF, tetrahydrofolate.
