Figure 1. Up-regulation of miR-497 mitigated VEGFR2 level and increased the levels of apoptosis related proteins in human umbilical vein endothelial cells (HUVECs).
(A) Using qRT-PCR analysis, the expression of miR-497 was increased in miR-497 mimic treatment and decreased in miR-497 inhibitor treatment in HUVECs. Data were expressed as mean ± SEM, n = 3; **P < 0.01 vs. control group, ##P < 0.01 vs. control group. (B–F) Protein levels of VEGFR2, Total Akt, p-Akt, Bax, and Bcl-2 were detected by western blotting assay. Data were expressed as mean ± SEM, n = 3; **P < 0.01 or ***P < 0.001 vs. control group.