Table 2. Overrepresented functional categories in candidate susceptibility genes (Pool 9).
| Category | Term | Count | % | P-Value | Enrichment |
|---|---|---|---|---|---|
| BP | cell death | 25 | 9 | 0.00037 | 2.20 |
| MF | transcription activator activity | 17 | 6 | 0.00052 | 2.70 |
| BP | transmembrane transport | 21 | 8 | 0.00062 | 2.40 |
| MF | ion transmembrane transporter activity | 24 | 9 | 0.00065 | 2.20 |
| MF | substrate-specific transmembrane transporter activity | 26 | 9 | 0.00076 | 2.10 |
| MF | transmembrane transporter activity | 27 | 10 | 0.00130 | 2.00 |
| CC | intracellular organelle | 155 | 56 | 0.00260 | 1.20 |
| MF | gated channel activity | 12 | 4 | 0.00770 | 2.50 |
| MF | binding | 204 | 74 | 0.00850 | 1.10 |
| MF | cation transmembrane transporter activity | 17 | 6 | 0.01100 | 2.00 |
| MF | anion binding | 6 | 2 | 0.01300 | 4.30 |
| BP | transport | 56 | 20 | 0.01400 | 1.40 |
| MF | transferase activity | 39 | 14 | 0.01400 | 1.50 |
| MF | ion channel activity | 13 | 5 | 0.01500 | 2.20 |
| CC | integral to plasma membrane | 28 | 10 | 0.01700 | 1.60 |
| MF | substrate specific channel activity | 13 | 5 | 0.01800 | 2.20 |
| CC | apical part of cell | 8 | 3 | 0.02100 | 3.00 |
| CC | plasma membrane part | 45 | 16 | 0.02200 | 1.40 |
| CC | ion channel complex | 8 | 3 | 0.03300 | 2.60 |
BP (Biological Process), MF(Molecular Function), CC (Cellular Component).