Table 3. K+ channel candidate susceptibility genes in pool 9.
Gene name | Description | esiRNA | EXP | REG | Evidence score |
---|---|---|---|---|---|
Kcna3 | Voltage-gated, shaker-related | 84% P <0.0001 | ++++ | −0.07 | 5 |
Kcnb2 | Voltage-gated delayed rectifier, Shab-related | 84% P = 0.03 | ++ | 0.07 | 4 |
Kcnip4 | Voltage-gated interacting protein, binds Ca2+ | 124% P = 0.01 | + | −0.22 | 1 |
Kcnj3 | K+ inwardly-rectifying channel | 83% | +++ | −0.07 | 5 |
Slc24a3 | Solute carrier, Ca2+/Na+/K+ exchanger | 107% | ++++ | −0.15 | 2 |
esiRNA: mean % killing relative to FLUC control. P calculated relative to FLUC control by 2-tailed t test.
EXP: level of colonic expression (+) 0–25%, (++) 25–50%, (+++) 50–75%, (++++) 75–100%.
REG: mean difference in gene expression between day 1 of acute amebiasis and day 60 (recovery) (n = 8, matched samples).