Table 4. Effect of channel inhibitors on amebic killing of UMUC3 cells.
| Inhibitor |
No washout |
Washout |
||
|---|---|---|---|---|
| IC50(μm) | ICmax(% killing) | IC50(μm) | ICmax(% killing) | |
| ibutilide (IBU) | 4.4 | 47 (0%) | 4.7 | 47 (0%) |
| 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB) | 4.6 | 50 (6%) | 14.9 | 94 (10%) |
| benzamil (BNZ) | 8.2 | 50 (1%) | 4.4 | 47 (7%) |
| tetraethylammonium chloride (TEA) | 45.4 | 234 (0%) | 37.2 | 234 (11%) |
| diltazem (DIL) | 25.9 | 50 (12%) | 57.6 | 750 (25%) |
| 4-aminopyrimadine (4-AP) | 1366 | 188 (44%) | 807 | 188 (44%) |
| procaine (PRO) | 1571 | 375 (32%) | 35.8 | 4.7(9%) |
| quinine (QUI) | 712 | 47 (51%) | 653 | 47 (46%) |
ICmax- concentration with maximum inhibition of amebic cytotoxicity.
The % killing at the ICmax relative to untreated cells is shown in parenthesis.