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. 2015 Sep 8;5:13823. doi: 10.1038/srep13823

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Copyright © 2015, Macmillan Publishers Limited

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(a) Mevalonate is unable to rescue Simvastatin induced inhibition of glucose uptake: Mean basal and insulin stimulated (5 min and 10 min) uptake of 2-NBDG by L6 myotubes treated with Simvastatin (1 μM) and/or Mevalonate (500 μM) for 48 h. DMSO (0.1%) treated cells served as internal control. Values are shown as mean±SD after normalizing with the corresponding protein content and expressed relative to basal of control cells which was set to 1; **p < 0.01, versus corresponding control cells , ^nsnon significant, ^ap < 0.01 versus corresponding Simvastatin treated cells (two way ANOVA). (b) Total Cholesterol levels were depleted upon Simvastatin treatment: L6 myotubes were cultured for 48 h in presence of Simvastatin (1 μM) or Mevalonate (500 μM). Post treatment lipid was extracted and total cholesterol was estimated. Values were further normalized with the total cell count and represented as μM per million cells. **p < 0.01, ***p < 0.005 versus corresponding control (DMSO: 0.1%) cells, ^bp < 0.001 versus Simvastatin (1 μM) treated cells (two way ANOVA).