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. 2015 Sep 8;5:13883. doi: 10.1038/srep13883

Figure 2. Presence of circulating Th22 and Tc22 cells in EUs and HIV-1-infected subjects.

Figure 2

PBMCs of HCs (n = 15), EUs (n = 16) and HIV-infected individuals (n = 15) were cultivated with medium (baseline), HIV Gag peptide pools [Gag1 (p17), Gag2 (p24), and Gag3 (p15)], or SEB for 6 h and Brefeldin A for 4 h. Th22 and Tc22 cell frequencies were obtained by excluding IFN-γ and IL-17a. (A) Th22 and (B) Tc22 cell frequencies were assessed using flow cytometry. Frequencies of Th22 or Tc22 cells were subtracted from baseline levels. The results are shown as medians and IQRs. *p ≤ 0.05, **p ≤ 0.01 and ***p ≤ 0.001, adjusted for multiple comparisons.