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. 2015 Sep 8;5:13883. doi: 10.1038/srep13883

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Copyright © 2015, Macmillan Publishers Limited

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The simultaneous secretion of IFN-γ, IL-2, IL-17a, IL-22, and MIP-1β by CD4+ (A) and CD8+ T (B) cells expressing CD38 or not expressing CD38, induced by Gag1 (p17), Gag2 (p24), Gag3 (p15) or SEB, from HCs (n = 15), EUs (n = 16) and HIV-infected individuals (n = 15) was assessed using flow cytometry. (C) Pie chart representations of the capacity of CD4+CD38+ and CD4+CD38- T cells to secrete 5, 4 or 3 cytokines (IL-17a, IL-22, IFN-γ, MIP-1β and IL-2) induced by SEB. Frequencies of CD4+ and CD8+ T cells were subtracted from baseline values. Bars represent the medians and IQRs. *p ≤ 0.05 and **p ≤ 0.01, adjusted for multiple comparisons.