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Blocking JNK activity inhibited the in vivo tumor-initiating ability of acquired chemoresistant cancer cells. (A) Expression of phosphorylated c-Jun, Flag, and GFP in KB/VCR cells after infection with GFP or JNK DM lentiviruses. (B) Tumor formation of KB or KB/VCR cells after infection with lentiviruses harboring GFP, JNK DM, or JNK1/2 shRNA. Mean±SD. n=3. bP<0.05.
