Table 3.
Nominal half-life values of human proteins in human serum
| Protein | Nominal half-life (hours) | Molecular mass (kDa) | Ratio of half-life to molecular mass |
|---|---|---|---|
| HSA | 456 | 67 | 6.8 |
| Transferrin | 288 | 80 | 3.6 |
| IgG1, IgG2, IgG4 | 480 | 146 | 3.3 |
| IgG3 | 144 | 165 | 0.87 |
| IgA monomer | 120 | 160 | 0.75 |
| Retinol-binding protein | 12 | 21 | 0.57 |
| Factor H | 87 | 155 | 0.56 |
| Factor XIII | 168 | 320 | 0.5 |
| C-reactive protein | 48 | 125 | 0.38 |
| Factor IX | 22 | 57 | 0.38 |
| Fibrinogen | 100 | 340 | 0.29 |
| IFN-α | 5 | 19 | 0.26 |
| IgE | 48 | 188 | 0.25 |
| Pentameric IgM | 144 | 970 | 0.15 |
| IL-2 | 1.7 | 15 | 0.11 |
| Thyroglobulin | 65 | 660 | 0.1 |
| G-CSF | 2 | 20 | 0.1 |
| Factor VIIa | 3 | 50 | 0.06 |
| PYY3–36 | 0.13 | 4 | 0.03 |
| IGF-1 | 0.17 | 8 | 0.02 |
| hGH | 0.3 | 22 | 0.014 |
| GLP-1 | 0.03 | 4 | 0.008 |
G-CSF granulocyte colony-stimulating factor, GLP glucagon-like peptide, hGH human growth hormone, HSA human serum albumin, IFN interferon, Ig immunoglobulin, IGF insulin-like growth factor, IL interleukin, PYY peptide tyrosine tyrosine