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. 2015 Jul 16;29(4):215–239. doi: 10.1007/s40259-015-0133-6
Biobetters are biologics based on an innovative biologic but with improved properties.
Fusion proteins have been used in the biopharmaceutical industry for over 25 years to improve the pharmacokinetic properties of otherwise short-half-life biologics.
Biobetter fusion proteins with longer half-lives or with targeting moieties are being developed for several innovative biologic drugs.