Table 5.67.1.

Most Commonly Used SOD1 Mice to Study ALS

Mutation carrier	Promotor	Reference	CNS overexpression (fold)	Activity	Disease onset (months)	Survival (months)	Paralysis	Aggregation	Motor neuron loss
G93A	Human SOD1	Gurney et al., [*AU; provide this ref.]	17	13	3	4	Yes		Yes
G37R	Human SOD1	Wong et al., 1995	4-12	5-14	3.5-6	7	Yes	SOD1 accumulation in axons	Yes
G85R	Human SOD1	Bruijn et al., 1997	0.2-1	0	8	8.5	Yes	astrocyte SOD1 inclusions	40% MN loss
G86R	Mouse sodl	Ripps et al., 1995	Low to high	0	3-4 (line M1)	4	yes	NA	yes

[*Author: We created this table from the spreadsheet of data you submitted. Please check all cells and headings carefully to make sure the information is presented thoroughly and correctly.]

^*Author: Define “Activity” and provide units, if appropriate.