Table 5.
Cox regression analyses for mortality in the derivation sample
| Variable | Category | Univariate analysis | Multivariate analysis π | ||
|---|---|---|---|---|---|
| n subjects included = 93 | |||||
| HR (95% CI)* | P value | HR (95% CI)* | P value | ||
| Gender | Male vs Female | 1.03 (0.59-1.79) | NS | ||
| Age (years) | 1.02 (1.0-1.05) | NS | |||
| IDU | Yes vs No | 1.04 (0.66-1.66) | NS | ||
| AIDS defining event | Yes vs No | 1.73 (1.09-2.73) | 0.019 | 2.02 (1.01-4.02) | 0.045 |
| HBV or/and HCV co-infection | Yes vs No | 0.94 (0.60-1.49) | NS | ||
| cART | Yes vs No | 0.57 (0.35-0.95) | 0.032 | ||
| CD4 cell count, cell/mm3 | <200 vs ≥200 | 1.79 (1.12-2.88) | 0.015 | ||
| HIV-RNA undetectable | Yes vs No | 1.52 (0.84-2.73) | NS | ||
| PNI | <45 vs ≥45 | 2.42 (1.22-4.77) | 0.011 | 2.21 (1.11-4.40) | 0.023 |
Abbreviations: HR Hazard Ratio, 95% CI 95% Confidence Interval, IDU Intravenous Drug Use, HBV Hepatitis B Virus, HCV Hepatitis C Virus, cART combined Antiretroviral Therapy, PNI Prognostic Nutritional Index, NS Not Statistical Significant (p > 0.05).
*Adjusted for all the variables in the table. πThe mortality risk score based on the regression coefficients of the variables in final model was represented by 0.703*(AIDS defining event [yes =1/no = 0]) + 0.794 * (PNI) [AIDS defining event within six months from NHL diagnosis].