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. 2015 Sep 8;5:13632. doi: 10.1038/srep13632

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Copyright © 2015, Macmillan Publishers Limited

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(A) Illustration of CRISPR/Cas9 target sites and genetic regions of candidate genes. The left CRISPR target site was located on Chr. 5: 75,408,459–75,408,481 and the right target site was located on Chr. 5: 76,444,361–76,444,383. The genomic region between left and right targets contained the seven genes, Kit, Kdr, Srd5a3, Tmeme165, Clock, Pdcl2, and Nmu. (B) The depigmentation phenotype of Kit^WE/+ mice was the same as Kit^WS/+. (C) Genomic sequencing analysis exhibited that the genetic region between 75,804,497 and 76,875,127 on Chr. 5 was deleted. (D) Cultivated Kit^WE/WE blastocyst. Both ES (arrow) and TS (arrowheads) like-cells were seen. Sale Bar = 100 μm.