Table 2.
Prior and posterior estimates of model parameters. The prior parameter values are as given in ref. 12
| Parameter | Unit | Prior (mean±SD) | Posterior (mean) |
|---|---|---|---|
| rinlp | mg/dL/day | 28.46±1.13 | 28.93 |
| kkidney | pool/day | 2.42±0.78 | 2.57 |
| kdissoc | pool/day | 170±191 | 181.89 |
| γ | unitless | 10.17±2.19 | 8.58 |
| kCETPHV | pool/day | 1.49±0.24 | 1.49 |
| kCETPHL | pool/day | 6.92±0.81 | 6.87 |
| kCETPLH | pool/day | 2.89±0.34 | 2.93 |
| kVL | pool/day | 7.70±0.84 | 7.71 |
| kVLDLout | pool/day | 1.30±0.35 | 0.83 |
| kLDLout | pool/day | 0.64±0.07 | 0.57 |
| kHDLSRB1 | pool/day | 0.60±0.08 | 0.65 |
| kcholo | pool/day | 0.13±0.022 | 0.14 |
| klholo | pool/day/nm | −0.016±0.004 | −0.015 |
| kf | 1/(mmol/dL) | 50000±15440 | 50005 |
| kApoBout | pool/day | – | 0.57 |
| kLDLout,linear | pool/day | – | −0.31 |
| kABCA1 | pool/day | 95.18±15.73 | 80 mg: 100.01 |
| 180 mg: 90.67 | |||
| 420 mg: 93.77 | |||
| rinVLDL | mg/dL/day | 1.50±0.45 | 80 mg: 1.10 |
| 180 mg: 2.41 | |||
| 420 mg: 1.42 | |||
| rApoBin | mg/dL/day | 55.11±6.5 | 80 mg: 43.78 |
| 180 mg: 43.61 | |||
| 420 mg: 39.55 | |||
| Emax | unitless | – | 0.91 |
| EC50 | ng/mL | – | 6.7 |