Table 3.
Top 4 drug combinations showing increased risk, based on LFDR values
| Drug_1 | Drug_2 | Drug_3 | Drug_4 | Sample size |
|
Risk |
|---|---|---|---|---|---|---|
| Acetaminophen | Duloxetine | Oxycodone | Hydrocodone | 679 | 91.808 | 0.358 |
| Acetaminophen | Alprazolam | Oxycodone | Hydrocodone | 1,179 | 79.761 | 0.260 |
| Acetaminophen | Alprazolam | Duloxetine | Hydrocodone | 618 | 72.642 | 0.332 |
| Acetaminophen | Duloxetine | Hydrocodone | Tramadol | 499 | 71.420 | 0.369 |
| Acetaminophen | Duloxetine | Hydrocodone | Zolpidem | 533 | 63.601 | 0.334 |
| Acetaminophen | Oxycodone | Hydrocodone | Zolpidem | 666 | 59.200 | 0.290 |
| Acetaminophen | Alprazolam | Duloxetine | Oxycodone | 322 | 47.981 | 0.376 |
| Acetaminophen | Alprazolam | Hydrocodone | Zolpidem | 757 | 47.840 | 0.252 |
| Acetaminophen | Oxycodone | Hydrocodone | Tramadol | 800 | 47.201 | 0.246 |
| Acetaminophen | Duloxetine | Oxycodone | Tramadol | 255 | 45.131 | 0.416 |
Bold represents drug combinations reported for myopathy in SIDER 2.