Table 4.
Top 5 drug combinations showing increased risk, based on LFDR values
| Drug_1 | Drug_2 | Drug_3 | Drug_4 | Drug_5 | Sample size |
|
Risk |
|---|---|---|---|---|---|---|---|
| Acetaminophen | Alprazolam | Duloxetine | Oxycodone | Hydrocodone | 209 | 36.591 | 0.397 |
| Acetaminophen | Duloxetine | Oxycodone | Hydrocodone | Tramadol | 174 | 32.136 | 0.408 |
| Acetaminophen | Duloxetine | Oxycodone | Hydrocodone | Zolpidem | 171 | 31.777 | 0.409 |
| Acetaminophen | Alprazolam | Oxycodone | Hydrocodone | Zolpidem | 221 | 30.884 | 0.353 |
| Acetaminophen | Alprazolam | Duloxetine | Hydrocodone | Zolpidem | 174 | 27.374 | 0.374 |
| Acetaminophen | Duloxetine | Hydrocodone | Zolpidem | Tramadol | 114 | 24.160 | 0.439 |
| Acetaminophen | Oxycodone | Hydrocodone | Zolpidem | Tramadol | 139 | 22.126 | 0.374 |
| Acetaminophen | Alprazolam | Duloxetine | Oxycodone | Zolpidem | 99 | 20.777 | 0.434 |
| Simvastatin | Acetaminophen | Duloxetine | Oxycodone | Hydrocodone | 112 | 18.894 | 0.384 |
| Acetaminophen | Alprazolam | Oxycodone | Hydrocodone | Tramadol | 235 | 17.745 | 0.272 |
Bold represents drug combinations reported for myopathy in SIDER 2.