Table 5.
Top 6 drug combinations showing increased risk, based on LFDR values
| Drug_1 | Drug_2 | Drug_3 | Drug_4 | Drug_5 | Drug_6 | Sample size |
|
Risk |
|---|---|---|---|---|---|---|---|---|
| Acetaminophen | Alprazolam | Duloxetine | Oxycodone | Hydrocodone | Zolpidem | 66 | 17.699 | 0.485 |
| Acetaminophen | Duloxetine | Oxycodone | Hydrocodone | Zolpidem | Tramadol | 42 | 14.013 | 0.548 |
| Acetaminophen | Alprazolam | Oxycodone | Hydrocodone | Zolpidem | Tramadol | 57 | 13.030 | 0.439 |
| Acetaminophen | Alprazolam | Duloxetine | Oxycodone | Hydrocodone | Tramadol | 53 | 10.150 | 0.396 |
| Acetaminophen | Alprazolam | Duloxetine | Oxycodone | Zolpidem | Tramadol | 24 | 10.115 | 0.625 |
| Simvastatin | Acetaminophen | Alprazolam | Duloxetine | Oxycodone | Hydrocodone | 36 | 9.692 | 0.472 |
| Acetaminophen | Alprazolam | Duloxetine | Hydrocodone | Zolpidem | Tramadol | 41 | 9.666 | 0.439 |
| Alprazolam | Duloxetine | Oxycodone | Hydrocodone | Zolpidem | Tramadol | 18 | 7.607 | 0.611 |
| Simvastatin | Acetaminophen | Duloxetine | Oxycodone | Hydrocodone | Zolpidem | 34 | 7.345 | 0.412 |
| Acetaminophen | Duloxetine | Oxycodone | Hydrocodone | Zolpidem | Fluoxetine | 32 | 6.811 | 0.406 |
Bold drugs are reported for myopathy in SIDER 2.