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. 2015 Jul 6;4(8):481–488. doi: 10.1002/psp4.59

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© 2015 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Directional DDI tree for 3-drug combination (hydrocodone, acetaminophen, oxycodone). The value shown on each node indicates the OR of the myopathy risk associated with taking the current drug on top of all the other drugs from the root to the current node. The node size is proportional to the OR. Green indicates OR <1, and red indicates OR >1.