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Contingency table for examining directional effects from taking drug combination (
,
, …,
) to taking drug combination (
,
, …,
,
), where
is a newly added drug to be co-committed with the existing drug combination (
,
, …,
)
| With myopathy | Without myopathy | Total | |
|---|---|---|---|
| With (D1, D2, …, Dn-1, Dn) | a | b | a+b |
| With (D1, D2, …, Dn-1) and without Dn | c | d | c+d |
| Total | a+c | b+d | a+b+c+d |
The odds ratio (OR) of the myopathy risk associated with adding
to (
,
, …,
) is defined as OR = (a×d)/(b×c).
