Table 3.
Odd ratios (ORs) of the myopathy risk associated with taking D2 on top of D1: Top 10 findings for Ntake ≥ MinSup, where Ntake is the number of events where both drugs were co-committed during the event window
| D1 | D2 | OR | LCI | UCI | Ntake | Ranking | |
|---|---|---|---|---|---|---|---|
| MinSup = 200 | MinSup = 1,000 | ||||||
| Ethinyl-Estradiol | Tizanidine | 24.68 | 20.04 | 30.39 | 431 | 1 | |
| Bupropion | Tizanidine | 24.01 | 19.43 | 29.66 | 367 | 2 | |
| Singulair | Tizanidine | 22.64 | 18.56 | 27.62 | 411 | 3 | |
| Loratadine | Tizanidine | 19.33 | 14.75 | 25.33 | 217 | 4 | |
| Quetiapine | Tizanidine | 18.01 | 14.07 | 23.05 | 269 | 5 | |
| Phenylephrine | Acetaminophen | 17.91 | 12.39 | 25.90 | 208 | 6 | |
| Estradiol | Tizanidine | 17.80 | 14.15 | 22.39 | 350 | 7 | |
| Risperdal | Acetaminophen | 16.32 | 12.29 | 21.66 | 267 | 8 | |
| Hydrochlorothiazide | Tizanidine | 15.94 | 12.48 | 20.35 | 296 | 9 | |
| Dextromethorphan | Acetaminophen | 15.84 | 12.66 | 19.83 | 446 | 10 | |
| Ethinyl-Estradiol | Tramadol | 14.01 | 12.12 | 16.19 | 1,249 | 1 | |
| Loratadine | Acetaminophen | 10.09 | 8.88 | 11.45 | 1,379 | 2 | |
| Estradiol | Cymbalta | 9.06 | 7.82 | 10.50 | 1,312 | 3 | |
| Ethinyl-Estradiol | Cymbalta | 8.96 | 7.82 | 10.26 | 1,924 | 4 | |
| Ethinyl-Estradiol | Acetaminophen | 8.83 | 7.75 | 10.07 | 2,134 | 5 | |
| Loratadine | Hydrocodone | 8.58 | 7.50 | 9.81 | 1,262 | 6 | |
| Estradiol | Acetaminophen | 8.36 | 7.27 | 9.62 | 1,555 | 7 | |
| Phenylephrine | Hydrocodone | 7.64 | 5.97 | 9.77 | 2,791 | 8 | |
| Loratadine | Alprazolam | 7.49 | 6.51 | 8.62 | 1,190 | 9 | |
| Estradiol | Hydrocodone | 6.93 | 5.93 | 8.10 | 1,365 | 10 | |
Drugs reported for myopathy in SIDER 2 are shown in bold. LCI and UCI indicate the lower and upper limits of the confidence interval, respectively.