. 2015 Jul 6;4(8):481–488. doi: 10.1002/psp4.59

Table 4.

Odd ratios (ORs) of the myopathy risk associated with taking D₃ on top of D₁ and D₂: Top 10 findings for N_take ≥ MinSup, where N_take is the number of events where all three drugs were co-committed during the event window

D₁	D₂	D₃	OR	LCI	UCI	N_take	Ranking
D₁	D₂	D₃	OR	LCI	UCI	N_take	MinSup = 200	MinSup = 1,000
Ethinyl-Estradiol	Estradiol	Tramadol	10.96	8.60	13.96	481	1
Ethinyl-Estradiol	Estradiol	Oxycodone	10.53	7.65	14.49	272	2
Ethinyl-Estradiol	Estradiol	Cymbalta	10.51	8.65	12.78	813	3
Ethinyl-Estradiol	Loestrin	Cymbalta	9.64	6.75	13.78	242	4
Estradiol	Loestrin	Cymbalta	9.64	6.75	13.78	242	5
Ethinyl-Estradiol	Estradiol	Acetaminophen	7.87	6.40	9.67	871	6
Hydrocodone	Loestrin	Acetaminophen	7.37	0.98	55.76	203	7
Topamax	Butalbital	Acetaminophen	7.30	0.98	54.32	317	8
Ethinyl-Estradiol	Drospirenone	Cymbalta	7.12	4.55	11.15	212	9
Estradiol	Drospirenone	Cymbalta	7.12	4.55	11.15	212	10
Phenylephrine	Chlorpheniramine	Hydrocodone	6.77	4.84	9.47	1,046		1
Hydrocodone	Warfarin	Acetaminophen	5.67	0.77	41.67	1,168		2
Hydrocodone	Acetaminophen	Tizanidine	4.99	4.49	5.55	1,553		3
Hydrocodone	Loratadine	Acetaminophen	4.54	2.68	7.71	1,077		4
Hydrocodone	Pioglitazone	Acetaminophen	4.42	1.07	18.24	1,061		5
Ethinyl-Estradiol	Estradiol	Alprazolam	4.41	3.49	5.58	1,008		6
Hydrocodone	Celebrex	Acetaminophen	4.32	1.34	13.91	1,308		7
Hydrocodone	Hydrochlorothiazide	Acetaminophen	3.75	1.51	9.28	1,362		8
Hydrocodone	Acetaminophen	Topamax	3.70	3.26	4.20	1,142		9
Hydrocodone	Bupropion	Acetaminophen	3.49	1.68	7.26	1,362		10

Drugs reported for myopathy in SIDER 2 are shown in bold. LCI and UCI indicate the lower and upper limits of the confidence interval, respectively.