Table 2.
Demographic, cognitive test and scale scores by diagnostic group
| Variable | HC (n = 219) | MCI (n = 299) | AD dementia (n = 100) | p-value* |
|---|---|---|---|---|
| Age (years) | 77.69 ± 6.24 (63–94) | 74.19 ± 7.91 (56–92) | 77.58 ± 7.62 (56–92) | <.0001 |
| Sex (% male) | 50.68 | 60.87 | 67.00 | .0103 |
| Education (years) | 16.42 ± 2.72 (6–20) | 16.18 ± 2.76 (8–20) | 15.75 ± 3.08 (3–20) | .1353 |
| MMSE | 29.07 ± 1.24 (23–30) | 27.83 ± 1.92 (21–30) | 20.31 ± 4.70 (7–30) | <.0001 |
| % subjects with MMSE ≥24 | 99.54 | 98.33 | 21.00 | <.0001 |
| MoCA | 25.57 ± 2.75 (16–30) | 23.41 ± 3.38 (13–30) | 15.30 ± 5.51 (1–28) | <.0001 |
| % subjects with MoCA ≥17 | 99.54 | 96.32 | 48.00 | <.0001 |
| % subjects with MoCA ≥19 | 99.09 | 90.97 | 36.00 | <.0001 |
| % subjects with MoCA ≥23 | 87.67 | 65.89 | 7.00 | <.0001 |
| FAQ | 0.30 ± 1.06 (0–10) | 3.01 ± 4.20 (0–25) | 18.63 ± 6.94 (4–30) | <.001 |
| % subjects with abnormal FAQa | 0 % | 1.7 % | 60 % | <.001 |
Data are expressed as mean ± SD (range) except where frequencies are used for categorical data
AD Alzheimer’s disease, ANOVA analysis of variance, HC healthy control, FAQ Functional Activities Questionnaire, MCI mild cognitive impairment, MMSE Mini Mental State Exam, MoCA Montreal Cognitive Assessment, SD standard deviation
*chi-square test for categorical variables; F test (ANOVA) for continuous variables
aabnormal FAQ defined as at least 3 items each with a score of 3 points