Table 2.

INFORM measures at each stage of the study

	Measure or Instrument name	INTERVAL	INFORM baseline	INFORM follow-up	Mode of assessment	Note
Primary outcome	Physical Activity Level*	✓	✓	✓	accelerometers	using the Axivity AX3 – 3Axis logging Accelerometer®
Secondary outcomes	Traditional risk factors
	Fruit and vegetables intake	✓		✓	carotenoids
	Weight		✓	✓	self-report	as used in Godino et al. [56] and Knowles et al. [48]
	Cholesterol Panel (total, HDL and LDL cholesterol, triglycerides)	✓		✓	blood serum
	Fructosamine	✓		✓	blood serum
	Nutrition Behaviour (fruit, vegetables, whole grains, fish, red and processed meat)		✓	✓	self-report	one-item questions that reflect the present prevention guidelines on CVD [16, 10]
	Physical Activity Level		✓	✓	self-report	EPIC-Norfolk Physical Activity Questionnaire [60]
	Smoking Status		✓	✓	self-report
	Alcohol Consumption		✓	✓	self-report
	Current Medication and Healthcare Usage		✓	✓	self-report	adapted version of the Health Services Research Unit Aberdeen questionnaire [61]
	Perceived risk
	Comparative and Absolute Cardiovascular Risk		✓	✓	self-report	adapted according to Diefenbach et al. [62] and used in other risk communication studies [48, 56]
	Cognitive evaluation of provision of coronary heart disease risk scores
	Understanding of Risk Scores			✓	self-report	as used in another trial of risk communication [56]
	Perceived Accuracy of Risk Scores			✓	self-report	as used in other risk communication studies [48, 56]
	Acceptability of the Intervention			✓	self-report	in line with the Heart to Health study [50]
	Psychological outcomes
	Stress		✓	✓	self-report	as used in the Randomized Trial of Personal Genomics for preventive cardiology [48]
	Mood		✓	✓	self-report	adapted from the Patient Health Questionnaire [63]
	Coronary Heart Disease-related Worry		✓	✓	self-report	an adaptation of the Cancer Related Worry Scale [64]
	Genetic Risk-related Worry/Anxiety		✓		self-report	as used by Knowles et al. [48]
Moderators and mediators	Sociodemographic characteristics
	Sex, Age, Ethnicity	✓			self-report
	Marital Status		✓		self-report
	Socioeconomic Status (level of education, level of income, living area)		✓		self-report	adapted from the European Health Interview Survey; deprivation level of the area based on the Index of Multiple Deprivation, Department for Communities and Local Government
	Numeracy Skills		✓		self-report	3-item Schwartz scale [65]
	Family History of Coronary Heart Disease		✓		self-report
	History of Genetic Testing		✓		self-report
	History of Coronary Heart Disease Risk Assessment		✓		self-report
	Self-rated Health		✓	✓	self-report	Ware et al. [66]
	Barriers to risk-reducing strategy		✓		self-report	in line with the Heart to Health study [50]
	Cognitive and emotional theory-based antecedents to behaviour change
	Intentions		✓		self-report	adapted according to Ajzen [67] and used in previous similar research [56]
	Perception of Diet		✓		self-report
	Perception of Physical Activity		✓		self-report
	Coronary heart disease risk Representations		✓		self-report	the Brief Illness Perceptions Questionnaire [68]
	Self-efficacy		✓		self-report	as used in previous behavioural research [56, 68]
	Response Efficacy		✓	✓	self-report	as used in previous behavioural research [52, 69]
	Social Support		✓		self-report	the Multidimensional Scale of Perceived Social Support [70]
	Time Orientation		✓		self-report	as used in a study by Peretti-Watel et al. [71]
	Sense of Coherence		✓		self-report	3-items scale, Lundberg et al. [72]
	Comparative Optimism		✓		self-report	comparative perceived risk

*participants who did not take part in physical activity monitoring during the INTERVAL Study will be required to undertake baseline activity monitoring over 7 days