Table 3.
Genes and genomes pathway analysis of miR-146a target genes
| Pathway | Gene Symbol | Gene Name |
|---|---|---|
| Apoptosis | IRAK1 | interleukin-1 receptor-associated kinase 1, |
| Cancer | APPL1 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; |
| SLC22A3 | solute carrier family 22 (extraneuronal monoamine transporter), member 3; | |
| ERBB4 | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); | |
| NOTCH1 | notch 1; | |
| SMAD4 | SMAD family member 4; | |
| CSF1R | colony stimulating factor 1 receptor; | |
| DOT1L | DOT1-like, histone H3 methyltransferase (S. cerevisiae); | |
| PTGFRN | prostaglandin F2 receptor negative regulator; | |
| IGF2BP1 | insulin-like growth factor 2 mRNA binding protein 1; | |
| BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein); | |
| RAD1 | RAD1 homolog (S. pombe); | |
| HIC2 | hypermethylated in cancer 2; | |
| MLL2 | myeloid/lymphoid or mixed-lineage leukemia 2; | |
| EDNRB | endothelin receptor type B; | |
| NOVA1 | neuro-oncological ventral antigen 1; | |
| ABL2 | v-abl Abelson murine leukemia viral oncogene homolog 2 | |
| Mapk pathway | TRAF6 | TNF receptor-associated factor 6 |
| Cell differentation | NOTCH1 | notch 1; |
| SRP14 | signal recognition particle 14 kDa (homologous Alu RNA binding protein); | |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3; | |
| GDNF | glial cell derived neurotrophic factor; | |
| SMAD4 | SMAD family member 4; | |
| SEMA3G | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G; | |
| MED1 | mediator complex subunit 1; | |
| LIPA | lipase A, lysosomal acid, cholesterol esterase; | |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila); | |
| Metabolic pathway | SLC22A3 | solute carrier family 22 (extraneuronal monoamine transporter), member 3; |
| PGP | phosphoglycolate phosphatase; | |
| LIPA | lipase A, lysosomal acid, cholesterol esterase; | |
| DLST | dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex); | |
| DOT1L | DOT1-like, histone H3 methyltransferase (S. cerevisiae); | |
| BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein; | |
| DGKG | diacylglycerol kinase, gamma 90 kDa; | |
| Neural disease | IRAK1 | interleukin-1 receptor-associated kinase 1; |
| MYT1 | myelin transcription factor 1; | |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila); | |
| LRRTM2 | leucine rich repeat transmembrane neuronal 2; | |
| GRID1 | glutamate receptor, ionotropic, delta 1; | |
| SORT1 | sortilin 1; | |
| BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein); | |
| SYT1 | synaptotagmin I; | |
| NPAS4 | neuronal PAS domain protein 4; | |
| MLL2 | myeloid/lymphoid or mixed-lineage leukemia 2; | |
| DNAL1 | dynein, axonemal, light chain 1; | |
| EDNRB | endothelin receptor type B; | |
| Binding protein | NOVA1 | neuro-oncological ventral antigen 1; |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D | |
| Signal trasduction | ABL2 | v-abl Abelson murine leukemia viral oncogene homolog 2; |
| NUMB | numb homolog (Drosophila); | |
| CNTFR | ciliary neurotrophic factor receptor; | |
| SRP14 | signal recognition particle 14 kDa (homologous Alu RNA binding protein); | |
| GDNF | glial cell derived neurotrophic factor; | |
| SMAD4 | SMAD family member 4; | |
| KCTD15 | potassium channel tetramerisation domain containing 15; | |
| NF2 | neurofibromin 2 (merlin); | |
| KLF4 | Kruppel-like factor 4 (gut); | |
| SCN3B | sodium channel, voltage-gated, type III, beta; | |
| NLGN1 | neuroligin 1; | |
| RIMS2 | regulating synaptic membrane exocytosis 2; | |
| Cardiovascular disease | ABL2 | v-abl Abelson murine leukemia viral oncogene homolog 2; |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2; | |
| EDNRB | endothelin receptor type B; | |
| Ubiquitin pathway | DCAF12 | DDB1 and CUL4 associated factor 12; |
| FBXW2 | F-box and WD repeat domain containing 2; | |
| WWP2 | WW domain containing E3 ubiquitin protein ligase 2; | |
| DTL | denticleless homolog (Drosophila); | |
| Trasport protein | SLC10A3 | solute carrier family 10 (sodium/bile acid cotransporter family), member 3; |
| ERBB4 | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); | |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2; | |
| SH3GL2 | SH3-domain GRB2-like 2; | |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1; | |
| GOSR1 | golgi SNAP receptor complex member 1; | |
| SLC39A1 | solute carrier family 39 (zinc transporter), member 1; | |
| SORT1 | sortilin 1; | |
| BTG2 | BTG family, member 2; | |
| Enzyme | ERBB4 | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); |
| ADARB1 | adenosine deaminase, RNA-specific, B1; | |
| USP3 | ubiquitin specific peptidase 3; | |
| KDM2B | lysine (K)-specific demethylase 2B; | |
| SIAH2 | seven in absentia homolog 2 (Drosophila); | |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family); | |
| LIPA | lipase A, lysosomal acid, cholesterol esterase; | |
| CNOT6L | ||
| TRDMT1 | CCR4-NOT transcription complex, subunit 6-like; | |
| MPPE1 | tRNA aspartic acid methyltransferase 1; | |
| DCP1A | DCP1 decapping enzyme homolog A (S. cerevisiae); | |
| DLGAP2 | discs, large (Drosophila) homolog-associated protein 2; | |
| Kinase protein associated | TRAF6 | TNF receptor-associated factor 6; |
| PCDH1 | protocadherin 1; | |
| Prion disease | NOTCH1 | notch 1 |
| Infection disease | APPL1 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; |
| PGP | phosphoglycolate phosphatase; | |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3; | |
| SMAD4 | SMAD family member 4; | |
| TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31 kDa; | |
| CD28 | CD28 molecule; | |
| WASF2 | WAS protein family, member 2; | |
| SRSF7 | serine/arginine-rich splicing factor 7; | |
| Trascriptor factor | MAFF | v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian); |
| CSF1R | colony stimulating factor 1 receptor; | |
| TAF9B | TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor; | |
| EIF5A2 | eukaryotic translation initiation factor 5A2; | |
| KLF4 | Kruppel-like factor 4 (gut); | |
| SP8 | Sp8 transcription factor; | |
| SOX5 | SRY (sex determining region Y)-box 5; | |
| Endocrine system | MED1 | mediator complex subunit 1; |
| TP53RK | TP53 regulating kinase; | |
| Cellular antigen | CD84 | CD84 molecule |
| Mirna survelliance | PPP2R3A | protein phosphatase 2, regulatory subunit B’, alpha; |
| RIMS2 | regulating synaptic membrane exocytosis 2; |