TABLE 7.
Details for Figures
| Figure | Consensus Diagnoses/Interpretations
|
Final Diagnosis (Genotyping Result) | |||
|---|---|---|---|---|---|
| Round 1* | Round 2* | Round 3 (With p57)* | p57* w | ||
| 2A-D | CHM (3/3) | CHM (3/3) | CHM (3/3) | Negative (3/3) | CHM (androgenetic diploidy) |
| 2E-H | CHM (3/3) | CHM (3/3) | CHM (3/3) | Negative (3/3) | CHM (androgenetic diploidy) |
| 2I-L | PHM (3/3) | PHM (3/3) | PHM (3/3) | Positive (3/3) | PHM (diandric triploidy) |
| 2M-P | PHM (2/3) | PHM (2/3) | CHM (3/3) | Negative (3/3) | CHM (androgenetic diploidy) |
| 3A-D | None | NM (2/3) | CHM (3/3) | Negative (3/3) | CHM (androgenetic diploidy) |
| 3E-H | NM (2/3) | NM (3/3) | NM (2/3) | Positive (3/3) | PHM (diandric triploidy) |
| 3I-L | PHM (2/3) | NM (3/3) | PHM (2/3) | Positive (3/3) | NM (abnormal villous morphology) (biparental diploidy, trisomy 16 and 21) |
| 3M-P | PHM (2/3) | PHM (2/3) | NM (2/3) | Positive (3/3)zy | NM (mosaic/chimeric) (androgenetic/biparental diploidy) |
*
Result (no. pathologists rendering the diagnosis/interpretation).
†
The p57 result for all observers for each case was concordant with the officially reported p57 interpretation.
‡
Two of 3 pathologists recognized a discordant pattern.
§
Mosaic/chimeric conception with p57 expression in villous cytotrophoblast but not in villous stromal cells (see Ronnett et al51 for additional details of p57 expression patterns in mosaic/chimeric conceptions).
CHM, complete hydatidiform mole (either classic or early type); NM, non-molar specimen; PHM, partial hydatidiform mole.