Table 5.

Salivary vaccine candidates from different sand flies species.

Sand fly species	Vaccine candidate	Protect against	Nature of protective immune response	Model	Family of the protein or protein	Function
P. papatasi	PpSP15	L. major (Valenzuela et al., 2001a; Oliveira et al., 2008)	Th1, DTH	Mice	OBP/SL1	Inhibitor of contact activation
Lu. longipalpis	Maxadilan	L. major (Morris et al., 2001)	Th1, Humoral immune response	Mice	Maxadilan	Vasodilatator
Lu. longipalpis	LJM19	L. infantum chagasi, L. braziliensis (Regis et al., 2008 ; Tavares et al., 2011 )	Th1	Hamsters
Lu. longipalpis	LJM11	L. major (Xu et al., 2011; Regis et al., 2012a)	Th1, DTH	Mice	Yellow	Serotonin binding
Lu. intermedia	Linb-11	L. brazileinsis (DeMoura et al., 2013)	Th1	Mice
Lu. longipalpis	LJM17	L. infantum chagasi (Collin et al., 2009)	Th1, DTH, IgG2	Dogs	Yellow	Serotonin binding
Lu. longipalpis	LJL143	L. infantum chagasi (Collin et al., 2009)	Th1, DTH, IgG2	Dogs	Lufaxin	Anti-coagulant

L., Leishmania; Th1, T helper type 1 immune response; DTH, delayed-type hypersensitivity; IgG2, Immunoglobulin G class 2.