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. 2015 Sep 1;3:e1213. doi: 10.7717/peerj.1213

Figure 7. Enzymes and regulatory proteins involved in lipolysis (Adapted from Lass et al., 2011).

Figure 7

Mammalian proteins are indicated above the arrows and their C. elegans orthologues (Lee et al., 2014) below. Triacylglycerol (TAG) is progressively hydrolysed to diacylglycerol (DAG), monoacylglycerol (MAG) and glycerol (G) by lipases specific for each of these steps: adipose triacylglycerol lipase (ATGL), hormone-sensitive lipase (HSL) and finally monoacylglycerol lipase (MGL). LID-1 and C37H5.3 were proposed to be orthologues of ABHD5/CGI58 in C. elegans (Lee et al., 2014; Xie & Roy, 2015). HSL also shows some activity in the first and third step. The access of ATGL and HSL to lipid droplets is regulated by perilipin, which is under the control of protein kinase A (PKA). W01A8.1 is proposed to be a perilipin orthologue in the present work.