. Author manuscript; available in PMC: 2015 Sep 8.

Published in final edited form as: J Mol Biol. 2013 Oct 9;425(24):5009–5019. doi: 10.1016/j.jmb.2013.10.007

Table 1.

The MAVS regulome categorized by mechanism of regulation.

Protein–protein interactions	Mitochondrial dynamics	Post-translational modifications (Ub or P)
LGP2 (+/−) [16,17,32–36]	Fusion (+)/fission (−) [44,58]	PSMA7 (−) (Ub) [73]
NLRX1 (−) [26,37–40]	MFN1 (+) [58,59]	PCBP2/AIP4 (−) (Ub) [76]
MFN1 (+) [58,59]	MFN2 (+) [44,58,61]	TRIM25 (+) (Ub) [81]
MFN2 (−) [43]	↑Δψ_m (+) [44]	Ndifp1/Smurf1 (−) (Ub) [83]
Tom70/Hsp90 (+) [45]	MAM (+) [58,61]	TSPAN6 (−) (Ub) [86]
IFIT3 (+) [50]	FAK (+) [62]	PLK1 (−) (P)^a [88]
gC1qR (−) [57]	COX5B/ATG5 (−) [67]	c-Abl (+) (P) [93]
UBXN1 (−) [54]

Ub, ubiquitination; P, phosphorylation; (+), positive regulation; (−), negative regulation.

PLK1 does not directly phosphorylate MAVS but, rather, may require phosphorylation of MAVS for docking of PLK1 at an upstream site prior to PLK1 binding near the C terminus of MAVS where it exerts regulatory activity.