Table 6. Prediction of CP or poor outcome at 18 months corrected age in preterm infants.
| Predictor | CP |
Poor outcomes |
||||||
|---|---|---|---|---|---|---|---|---|
| Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | |
| aEEG (n = 139) | 83.3 | 58.2 | 15.9 | 97.4 | 75.0 | 60.9 | 28.6 | 92.1 |
| HUS (n = 308) | 87.5 | 64.5 | 11.9 | 98.9 | 65.2 | 66.4 | 25.4 | 89.7 |
| MRI (n = 210) | 68.8 | 90.2 | 36.7 | 97.2 | 50.0 | 92.1 | 53.3 | 91.1 |
| aEEG + HUS (n = 139) | 83.3 | 78.7 | 27.0 | 98.0 | 66.7 | 79.1 | 40.0 | 91.9 |
| aEEG + MRI (n = 100) | 83.3 | 96.6 | 76.9 | 97.7 | 52.4 | 96.2 | 78.6 | 88.4 |
| HUS + MRI (n = 209) | 68.8 | 93.8 | 47.8 | 97.3 | 45.2 | 93.8 | 56.0 | 90.8 |
| aEEG + HUS + MRI (n = 100) | 83.3 | 96.6 | 76.9 | 97.7 | 52.4 | 96.2 | 78.6 | 88.4 |
The predictors are defined as severe abnormalities in aEEG recordings within 72 h, HUS, or MRI individually or in combination. CP: cerebral palsy, aEEG: amplitude-integrated electroencephalography HUS: head ultrasound, MRI: cranial magnetic resonance imaging, PPV: positive predictive value, NPV: negative predictive value. Poor outcome: patients died from brain damage or survived with one or more of CP, hypophrenia, or audio-visual disorder.