Table 1.
Clinical characteristics of subjects
| Never-obese | Obesea | P b | |
|---|---|---|---|
| n | 14 | 15 | |
| Age (years) | 45 ± 11 | 46 ± 11 | 0.93 |
| Weight (kg) | 69 ± 7 | 115 ± 11 | 3.4 × 10−13 |
| BMI (kg/m2) | 25.2 ± 2.5 | 41.4 ± 4.5 | 4.1 × 10−12 |
| Waist to hip ratio | 0.85 ± 0.06 | 0.98 ± 0.06 | 5.0 × 10−6 |
| Systolic blood pressure (mmHg) | 123 ± 19 | 138 ± 22 | 0.073 |
| Diastolic blood pressure (mmHg) | 74 ± 6 | 85 ± 9 | 6.0 × 10−4 |
| P-Glucose (mmol/l) | 5.1 ± 0.4 | 5.7 ± 1.2 | 0.053 |
| P-Insulin (mU/l) | 4.6 ± 2.3 | 16.0 ± 10.3 | 3.7 × 10−4 |
| P-Cholesterol (mmol/l) | 4.7 ± 1.0 | 4.9 ± 0.7 | 0.57 |
| P-HDL Cholesterol (mmol/l) | 1.5 ± 0.4 | 1.1 ± 0.3 | 0.0058 |
| P-Triglycerides (mmol/l) | 0.86 ± 0.72 | 1.67 ± 0.92 | 0.013 |
| P-NEFA (mmol/l) | 0.57 ± 0.17 | 0.83 ± 0.16 | 2.4 × 10−4 |
| P-Apolipoprotein B (g/l) | 0.83 ± 0.25 | 0.96 ± 0.25 | 0.19 |
| P-Apolipoprotein A1 (g/l) | 1.39 ± 0.22 | 1.19 ± 0.24 | 0.028 |
| Mean fat cell volume (pl) | 443 ± 169 | 994 ± 184 | 5.5 × 10−9 |
aThree of the obese women had type 2 diabetes, of which two were treated with diet plus metformin, and one woman with diet alone. Nine were treated for hypertension and one patient had stable multiple sclerosis and did not receive any drugs
bComparison of control and obese group with unpaired t test. Values are mean ± SD