Table 3.
Primary analysis point (4 weeks)
| Variable | Three sessions | One session | Total | P-Value† | 95% Confidence Interval | Adjusted coefficient ** (95% Confidence Interval) |
|---|---|---|---|---|---|---|
| N with sufficient NRS scores over 4 weeks to calculate AUC | 43 | 81 | 124 | |||
| AUC (Cubic) by Week 4 Breathlessness NRS: mean (SD) | ||||||
| Worst | 22•86(7•12) | 22•58(7•10) | 22•68(7•08) | 0•83 | (-2•31, 2•87) | 1•05 (-1•64,3•75) |
| Average | 19•45(6•51) | 19•14(6•27) | 19•24(6•33) | 0•79 | (-2•00, 2•62) | 0•81 (-1•48,3•10) |
| Distress* (NHI =42, NLI = 84) | 16•23(7•17) | 12•29(8•27) | 13•60(8•11) | 0•01 | (0•98,6•91) | 3•24 (0•25,6•23) |
| Cope | 25•47(7.36) | 27.16(6.96) | 26.58(7.12) | 0.20 | (-4.27, 0.90) | −0.87 (-3.72,1.99) |
| Care | 31.02(8.62) | 31.11(8.13) | 31.08(8.27) | 0.95 | (-3.11,2.93) | 0.25 (-2.78,3.28) |
| Chronic Respiratory Questionnaire -SAS at Week 4: mean (SD) | N= 37 | N= 71 | N = 108 | |||
| Dyspnoea domain | 4•41(1•33) | 4•62(1•43) | 4•55(1•39) | 0•47 | (-0•77,0•35) | −0•38 (-0•89,0•13) |
| Fatigue | 3•36(1•05) | 3•47(1•25) | 3•43(1•18) | 0•63 | (-0•59,0•36) | 0•06 (-0•40,0•51) |
| Emotional Function | 4•59(1•08) | 4•68(1•13) | 4•65(1•11) | 0•69 | (-0•54,0•36) | 0•12 (-0•26,0•51) |
| Mastery | 4•44(1•25) | 5•03(1•15) | 4•83(1•21) | 0•02 | (-1•06,-0•11) | −0•34 (-0•75,0•07) |
Descriptive statistics of the primary and secondary breathlessness outcome measures, P-values and unadjusted and adjusted confidence intervals for the difference between the two arms
SAS self administered survey (supported by research nurse); SD standard deviation; AUC area under the curve; NHI number in three sessions arm; NLI number in one-session arm
*adjusted for baseline breathlessness intensity, gender, smoking status and age
†P-values based on student’s test with equal variance assumed