Table 5.
Clinical characteristics and outcome data of patients with stage IIIB NSCLC treated with neoadjuvant chemoradiation followed by surgical resection versus primary resection followed by adjuvant chemoradiation – Continuous variables are displayed as mean +/- standard deviation. Categorical variables are displayed as number (% total).
| Patient Characteristics | Neoadjuvant treatment n= 985 | Adjuvant treatment n=258 | p-Value | |
|---|---|---|---|---|
| Age at diagnosis (years) | 59.0 +/- 10.0 | 62.3 +/- 10.0 | <0.001 | |
| Male Gender | 557 (57%) | 142 (55%) | 0.67 | |
| Caucasian | 876 (89%) | 216 (83%) | 0.02 | |
| Academic Center | 412 (43%) | 73 (29%) | <0.001 | |
| Annual Income > $35,000 | 718 (73%) | 157 (61%) | <0.001 | |
| Urban Population Area | 661 (67%) | 162 (63%) | 0.16 | |
| Charlson/Deyo Score (CCI) | 0 | 515 (73%) | 151 (58%) | <0.001 |
| 1 | 156 (22%) | 76 (29%) | ||
| 2 | 30 (4%) | 32 (12%) | ||
| Tumor Size (mm) | 53.5 +/- 35.7 | 38.3 +/- 26.0 | <0.001 | |
| AJCC Clinical N Stage | 2 | 569 (63%) | 148 (64%) | 0.82 |
| 3 | 338 (37%) | 85 (36%) | ||
| Negative Margin (R0 resection) | 815 (83%) | 146 (56%) | <0.001 | |
| Median Overall Survival (months) | 30.0 +/- 1.7 | 26.6 +/- 2.8 | 0.06 | |