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. Author manuscript; available in PMC: 2016 May 5.
Published in final edited form as: Cell Rep. 2015 Apr 23;11(5):821–834. doi: 10.1016/j.celrep.2015.03.070

Figure 5. The chromatin composition of Drosophila replication origins.

Figure 5

(A) Percentage overlap of S2 origin peaks with DHSs and random expectation. (B) Efficiency of S2 origins localizing within (+) or outside (−) DHSs. (C) Average DNase-Seq enrichment within ± 2.5 kb of S2 RSSs and within ten sets of randomized genomic regions (Rand). The thick gray line traces average background values. (D) Spatial distribution of SNS-Seq signal within ± 2.5 kb of S2 RSSs (top), metaprofiles comparing origins with ten sets of randomized genomic regions (middle), and further partitioning of the signal above in four timing classes (L: late S-phase; M: mid; E: early) based on replication timing quartiles (bottom). (E) Same as (D) for MNase-Seq. (F-G) Same as (C) for the indicated features. p-values are from Wilcoxon rank-sum test. See also Figure S5.