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. Author manuscript; available in PMC: 2015 Sep 8.
Published in final edited form as: Anticancer Res. 2010 Nov;30(11):4573–4578.

Table II.

The dose-effect relationship parameters and mean CI values of carboplatin, gemcitabine or in combination.

Drug combination Dose-effect parameters CI values
Dm (µM) r IC50 IC75 IC90 IC95
Carbo 4 h 290.48±20.4 0.990
Gem 4 h 0.085±0.002 0.993
Gem 4h before carbo 4 h 127.16±7.61 0.999 0.88±0.06
Syn
0.66±0.05
Syn
0.52±0.05
Syn
0.44±0.04
Syn
Carbo 0.5 h before carbo + gem 3.5 h 119.03±5.42 0.994 0.82±0.04
Syn
0.63±0.01
Syn
0.50±0.01
Syn
0.44±0.02
Syn
Carbo 4 h before gem 4 h 148.08±3.39 0.997 1.02±0.03
Ant
1.08±0.01
Ant
1.17±0.01
Ant
1.26±0.02
Ant

Carbo: carboplatin; Gem: gemcitabine; Syn: synergism; Ant: antagonism.