Table II.
The dose-effect relationship parameters and mean CI values of carboplatin, gemcitabine or in combination.
| Drug combination | Dose-effect parameters | CI values | ||||
|---|---|---|---|---|---|---|
| Dm (µM) | r | IC50 | IC75 | IC90 | IC95 | |
| Carbo 4 h | 290.48±20.4 | 0.990 | — | — | — | — |
| Gem 4 h | 0.085±0.002 | 0.993 | — | — | — | — |
| Gem 4h before carbo 4 h | 127.16±7.61 | 0.999 | 0.88±0.06 Syn |
0.66±0.05 Syn |
0.52±0.05 Syn |
0.44±0.04 Syn |
| Carbo 0.5 h before carbo + gem 3.5 h | 119.03±5.42 | 0.994 | 0.82±0.04 Syn |
0.63±0.01 Syn |
0.50±0.01 Syn |
0.44±0.02 Syn |
| Carbo 4 h before gem 4 h | 148.08±3.39 | 0.997 | 1.02±0.03 Ant |
1.08±0.01 Ant |
1.17±0.01 Ant |
1.26±0.02 Ant |
Carbo: carboplatin; Gem: gemcitabine; Syn: synergism; Ant: antagonism.